Study on the Anti-Inflammatory and Analgesic Mechanisms of Breast Lump Resolution Detergent in a Rat Model of Breast Hyperplasia

Objective: This study aimed to investigate the anti-inflammatory and analgesic mechanisms of a breast lump resolution detergent in rat model hyperplasia. Methods: A hyperplasia was established using injections estradiol benzoate combined with progesterone. The effects on nipple height diameter were observed, along its impact serum levels (E2), prolactin (PRL), progesterone (P). Additionally, examined morphological changes tissue. nodule blood rheology parameters also observed. Furthermore, effect assessed cotton ball granuloma experiment, observed writhing test. Results: reduced model, decreased E2, PRL, P, alleviated pathological It lowered hemorheological including whole high, medium, low shear viscosity, plasma red cell hematocrit, aggregation index, deformability electrophoresis time, erythrocyte sedimentation rate acute “blood stasis” model. weight granulomas mice number episodes caused by acetic acid. Conclusion: demonstrates favorable therapeutic treating hyperplasia, promoting circulation removing stasis, exerting properties, providing effects. downregulation E2 PRL upregulation P may be critical underlying efficacy.